2G7Q

Structure of the Light Chain of Botulinum Neurotoxin Serotype A Bound to Small Molecule Inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 451

Chain	Residue
B	HIS222
B	HIS226
B	GLU261

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 452

Chain	Residue
A	HIS222
A	HIS226
A	GLU261
A	AHL500

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE AHL A 500

Chain	Residue
A	HIS222
A	GLU223
A	HIS226
A	GLU261
A	ASP369
A	ZN452
A	PHE162
A	PHE193

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
A	LEU224
B	LEU224

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:15107500, ECO:0000269|PubMed:16846233, ECO:0007744|PDB:2G7P, ECO:0007744|PDB:2G7Q

Chain	Residue	Details
A	GLU223
A	ALA227
A	LEU262
B	GLU223
B	ALA227
B	LEU262

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Transition state stabilizer => ECO:0000305|PubMed:16846233

Chain	Residue	Details
A	LEU366
B	LEU366

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