2G27

Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring

Summary for 2G27

Entry DOI	10.2210/pdb2g27/pdb
Related	2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26
Descriptor	Renin, METHYL (6-{[(2R)-1-(4-{3-[(2-METHOXYBENZYL)OXY]PROPOXY}PHENYL)-6-OXOPIPERAZIN-2-YL]METHOXY}-1H-INDOL-1-YL)ACETATE (2 entities in total)
Functional Keywords	protein-ligand complexes, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P00797
Total number of polymer chains	2
Total formula weight	74307.79
Authors	Holsworth, D.D.,Jalaiea, M.,Zhanga, E.,Mcconnella, P. (deposition date: 2006-02-15, release date: 2006-06-13, Last modification date: 2011-07-13)
Primary citation	Holsworth, D.D.,Cai, C.,Cheng, X.M.,Cody, W.L.,Downing, D.M.,Erasga, N.,Lee, C.,Powell, N.A.,Ednunds, J.J.,Stier, M.,Jalaie, M.,Zhang, E.,McConnell, P.,Ryan, M.J.,Bryant, J.,Li, T.,Kasani, A.,Hall, E.,Subedi, R.,Rahim, M.,Maiti, S. Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring BIOORG.MED.CHEM.LETT., 16:2500-2504, 2006 Cited by PubMed: 16480874 DOI: 10.1016/j.bmcl.2006.01.084 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation