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2G1S

Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring

Summary for 2G1S
Entry DOI10.2210/pdb2g1s/pdb
Related2G1N 2G1O 2G1R 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27
DescriptorRenin, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE, ... (4 entities in total)
Functional Keywordsprotein-ligand complexes, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P00797
Total number of polymer chains2
Total formula weight74513.84
Authors
Holsworth, D.D.,Jalaiea, M.,Zhanga, E.,Mcconnella, P. (deposition date: 2006-02-14, release date: 2006-06-13, Last modification date: 2020-07-29)
Primary citationHolsworth, D.D.,Cai, C.,Cheng, X.M.,Cody, W.L.,Downing, D.M.,Erasga, N.,Lee, C.,Powell, N.A.,Ednunds, J.J.,Stier, M.,Jalaie, M.,Zhang, E.,McConnell, P.,Ryan, M.J.,Bryant, J.,Li, T.,Kasani, A.,Hall, E.,Subedi, R.,Rahim, M.,Maiti, S.
Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring
BIOORG.MED.CHEM.LETT., 16:2500-2504, 2006
Cited by
PubMed: 16480874
DOI: 10.1016/j.bmcl.2006.01.084
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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