2G27
Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring
Summary for 2G27
Entry DOI | 10.2210/pdb2g27/pdb |
Related | 2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 |
Descriptor | Renin, METHYL (6-{[(2R)-1-(4-{3-[(2-METHOXYBENZYL)OXY]PROPOXY}PHENYL)-6-OXOPIPERAZIN-2-YL]METHOXY}-1H-INDOL-1-YL)ACETATE (2 entities in total) |
Functional Keywords | protein-ligand complexes, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 74307.79 |
Authors | Holsworth, D.D.,Jalaiea, M.,Zhanga, E.,Mcconnella, P. (deposition date: 2006-02-15, release date: 2006-06-13, Last modification date: 2011-07-13) |
Primary citation | Holsworth, D.D.,Cai, C.,Cheng, X.M.,Cody, W.L.,Downing, D.M.,Erasga, N.,Lee, C.,Powell, N.A.,Ednunds, J.J.,Stier, M.,Jalaie, M.,Zhang, E.,McConnell, P.,Ryan, M.J.,Bryant, J.,Li, T.,Kasani, A.,Hall, E.,Subedi, R.,Rahim, M.,Maiti, S. Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring BIOORG.MED.CHEM.LETT., 16:2500-2504, 2006 Cited by PubMed: 16480874DOI: 10.1016/j.bmcl.2006.01.084 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
Download full validation report