2FX8

Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with an aib-induced peptide encompassing the 4e10 epitope on gp41

Summary for 2FX8

• Entry DOI: 10.2210/pdb2fx8/pdb
• Related: 1TZG 2FX7 2FX9
• Descriptor: Fab 4E10, Fragment of HIV glycoprotein (GP41), ... (4 entities in total)
• Functional Keywords: immunoglobulin fold, beta-sandwich, antibody-epitope complex, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: P05880
• Total number of polymer chains: 12
• Total formula weight: 195045.47

Authors

Cardoso, R.M.F.,Brunel, F.M.,Ferguson, S.,Burton, D.R.,Dawson, P.E.,Wilson, I.A. (deposition date: 2006-02-03, release date: 2006-12-19, Last modification date: 2023-11-15)

• Primary citation: Cardoso, R.M.,Brunel, F.M.,Ferguson, S.,Zwick, M.,Burton, D.R.,Dawson, P.E.,Wilson, I.A.; Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.; J.Mol.Biol., 365:1533-1544, 2007; PubMed: 17125793; DOI: 10.1016/j.jmb.2006.10.088

Experimental method

X-RAY DIFFRACTION (2.2 Å)