2FOI

Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase.

Summary for 2FOI

Entry DOI	10.2210/pdb2foi/pdb
Related	1NHD 1NHG 1NHW 1NNU 1ZSN 1ZW1
Descriptor	enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2,4-DICHLOROPHENOXY)-2'-METHYLBIPHENYL-3-OL, ... (5 entities in total)
Functional Keywords	enoyl reductase, rossmann fold, oxidoreductase
Biological source	Plasmodium falciparum More
Total number of polymer chains	4
Total formula weight	76405.39
Authors	Freundlich, J.S.,Shieh, H.,Anderson, J.W.,Kuo, M.,Yu, M.,Valderramos, J.,Karagyozov, L.,Tsai, H.,Lucumi, E.,Jacobs Jr., W.R.,Schiehser, G.A.,Jacobus, D.P.,Fidock, D.A.,Sacchettini, J.C. (deposition date: 2006-01-13, release date: 2007-01-16, Last modification date: 2023-08-30)
Primary citation	Freundlich, J.S.,Wang, F.,Tsai, H.C.,Kuo, M.,Shieh, H.M.,Anderson, J.W.,Nkrumah, L.J.,Valderramos, J.C.,Yu, M.,Kumar, T.R.,Valderramos, S.G.,Jacobs, W.R.,Schiehser, G.A.,Jacobus, D.P.,Fidock, D.A.,Sacchettini, J.C. X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy. J.Biol.Chem., 282:25436-25444, 2007 Cited by PubMed: 17567585 DOI: 10.1074/jbc.M701813200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation