2FOI

Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase.

2FOI の概要

• エントリーDOI: 10.2210/pdb2foi/pdb
• 関連するPDBエントリー: 1NHD 1NHG 1NHW 1NNU 1ZSN 1ZW1
• 分子名称: enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2,4-DICHLOROPHENOXY)-2'-METHYLBIPHENYL-3-OL, ... (5 entities in total)
• 機能のキーワード: enoyl reductase, rossmann fold, oxidoreductase
• 由来する生物種: Plasmodium falciparum; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 76405.39

構造登録者

Freundlich, J.S.,Shieh, H.,Anderson, J.W.,Kuo, M.,Yu, M.,Valderramos, J.,Karagyozov, L.,Tsai, H.,Lucumi, E.,Jacobs Jr., W.R.,Schiehser, G.A.,Jacobus, D.P.,Fidock, D.A.,Sacchettini, J.C. (登録日: 2006-01-13, 公開日: 2007-01-16, 最終更新日: 2023-08-30)

• 主引用文献: Freundlich, J.S.,Wang, F.,Tsai, H.C.,Kuo, M.,Shieh, H.M.,Anderson, J.W.,Nkrumah, L.J.,Valderramos, J.C.,Yu, M.,Kumar, T.R.,Valderramos, S.G.,Jacobs, W.R.,Schiehser, G.A.,Jacobus, D.P.,Fidock, D.A.,Sacchettini, J.C.; X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy.; J.Biol.Chem., 282:25436-25444, 2007; PubMed: 17567585; DOI: 10.1074/jbc.M701813200

実験手法

X-RAY DIFFRACTION (2.5 Å)