2FJM

The structure of phosphotyrosine phosphatase 1B in complex with compound 2

Summary for 2FJM

Entry DOI	10.2210/pdb2fjm/pdb
Related	2fjn
Descriptor	Tyrosine-protein phosphatase, non-receptor type 1, CHLORIDE ION, (4-{(2S,4E)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-[4-(METHOXYCARBONYL)PHENYL]-5-PHENYLPENT-4-ENYL}PHENYL)(DIFLUORO)METHYLPHOSPHONIC ACID, ... (5 entities in total)
Functional Keywords	phosphatase, secondary binding site, selectivity, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	73750.60
Authors	Asante-Appiah, E.,Patel, S.,Desponts, C.,Taylor, J.M.,Lau, C.,Dufresne, C.,Therien, M.,Friesen, R.,Becker, J.W.,Leblanc, Y.,Scapin, G. (deposition date: 2006-01-03, release date: 2006-01-17, Last modification date: 2023-08-30)
Primary citation	Asante-Appiah, E.,Patel, S.,Desponts, C.,Taylor, J.M.,Lau, C.,Dufresne, C.,Therien, M.,Friesen, R.,Becker, J.W.,Leblanc, Y.,Kennedy, B.P.,Scapin, G. Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase. J.Biol.Chem., 281:8010-8015, 2006 Cited by PubMed: 16407290 DOI: 10.1074/jbc.M511827200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation