2FJM
The structure of phosphotyrosine phosphatase 1B in complex with compound 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Tyrosine-protein phosphatase, non-receptor type 1 | polymer | 310 | 36224.1 | 2 | UniProt (P18031) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase 1B, PTP-1B |
| 2 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | A, B | (4-{(2S,4E)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-[4-(METHOXYCARBONYL)PHENYL]-5-PHENYLPENT-4-ENYL}PHENYL)(DIFLUORO)METHYLPHOSPHONIC ACID | non-polymer | 603.6 | 2 | Chemie (073) | |||
| 4 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | water | water | 18.0 | 299 | Chemie (HOH) |
Sequence modifications
A, B: 501 - 798 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Met 489 | - | cloning artifact |
| Asp 490 | - | cloning artifact |
| Tyr 491 | - | cloning artifact |
| Lys 492 | - | cloning artifact |
| Asp 493 | - | cloning artifact |
| Asp 494 | - | cloning artifact |
| Asp 495 | - | cloning artifact |
| Asp 496 | - | cloning artifact |
| Lys 497 | - | cloning artifact |
| Leu 498 | - | cloning artifact |
| Glu 499 | - | cloning artifact |
| Phe 500 | - | cloning artifact |
| Val 619 | Leu 119 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72448.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1302.3 | |
| All* | Total formula weight | 73750.6 |
