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2FJN

The structure of phosphotyrosine phosphatase 1B in complex with compound 2

Summary for 2FJN
Entry DOI10.2210/pdb2fjn/pdb
Related2FJM
DescriptorTyrosine-protein phosphatase, non-receptor type 1, CHLORIDE ION, (4-{(2S,4E)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-[4-(METHOXYCARBONYL)PHENYL]-5-PHENYLPENT-4-ENYL}PHENYL)(DIFLUORO)METHYLPHOSPHONIC ACID, ... (4 entities in total)
Functional Keywordsphosphatase, secondary binding site, selectivity, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains2
Total formula weight73754.35
Authors
Asante-Appiah, E.,Patel, S.,Desponts, C.,Taylor, J.M.,Lau, C.,Dufresne, C.,Therien, M.,Friesen, R.,Becker, J.W.,Leblanc, Y.,Kennedy, B.P.,Scapin, G. (deposition date: 2006-01-03, release date: 2006-01-17, Last modification date: 2023-08-30)
Primary citationAsante-Appiah, E.,Patel, S.,Desponts, C.,Taylor, J.M.,Lau, C.,Dufresne, C.,Therien, M.,Friesen, R.,Becker, J.W.,Leblanc, Y.,Kennedy, B.P.,Scapin, G.
Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.
J.Biol.Chem., 281:8010-8015, 2006
Cited by
PubMed: 16407290
DOI: 10.1074/jbc.M511827200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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