2FJN
The structure of phosphotyrosine phosphatase 1B in complex with compound 2
Summary for 2FJN
Entry DOI | 10.2210/pdb2fjn/pdb |
Related | 2FJM |
Descriptor | Tyrosine-protein phosphatase, non-receptor type 1, CHLORIDE ION, (4-{(2S,4E)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-[4-(METHOXYCARBONYL)PHENYL]-5-PHENYLPENT-4-ENYL}PHENYL)(DIFLUORO)METHYLPHOSPHONIC ACID, ... (4 entities in total) |
Functional Keywords | phosphatase, secondary binding site, selectivity, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 2 |
Total formula weight | 73754.35 |
Authors | Asante-Appiah, E.,Patel, S.,Desponts, C.,Taylor, J.M.,Lau, C.,Dufresne, C.,Therien, M.,Friesen, R.,Becker, J.W.,Leblanc, Y.,Kennedy, B.P.,Scapin, G. (deposition date: 2006-01-03, release date: 2006-01-17, Last modification date: 2023-08-30) |
Primary citation | Asante-Appiah, E.,Patel, S.,Desponts, C.,Taylor, J.M.,Lau, C.,Dufresne, C.,Therien, M.,Friesen, R.,Becker, J.W.,Leblanc, Y.,Kennedy, B.P.,Scapin, G. Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase. J.Biol.Chem., 281:8010-8015, 2006 Cited by PubMed: 16407290DOI: 10.1074/jbc.M511827200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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