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2FIE

Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitors

Summary for 2FIE
Entry DOI10.2210/pdb2fie/pdb
Related2FIX 2fhy
DescriptorFructose-1,6-bisphosphatase 1, 2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE (3 entities in total)
Functional Keywordsallosteric inhibitors human liver fbpase, benzoxazole, intersubunit allosteric inhibitors of human liver fbpase, hydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains4
Total formula weight149358.96
Authors
Abad-Zapatero, C. (deposition date: 2005-12-29, release date: 2006-02-21, Last modification date: 2023-08-30)
Primary citationLai, C.,Gum, R.J.,Daly, M.,Fry, E.H.,Hutchins, C.,Abad-Zapatero, C.,von Geldern, T.W.
Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.
Bioorg.Med.Chem.Lett., 16:1807-1810, 2006
Cited by
PubMed: 16446092
DOI: 10.1016/j.bmcl.2006.01.014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.81 Å)
Structure validation

217705

건을2024-03-27부터공개중

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