2FIE

Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006000	biological_process	fructose metabolic process
A	0006002	biological_process	fructose 6-phosphate metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006111	biological_process	regulation of gluconeogenesis
A	0016208	molecular_function	AMP binding
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0030308	biological_process	negative regulation of cell growth
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
A	0031667	biological_process	response to nutrient levels
A	0032869	biological_process	cellular response to insulin stimulus
A	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
A	0042578	molecular_function	phosphoric ester hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0045820	biological_process	negative regulation of glycolytic process
A	0046580	biological_process	negative regulation of Ras protein signal transduction
A	0046872	molecular_function	metal ion binding
A	0048029	molecular_function	monosaccharide binding
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070062	cellular_component	extracellular exosome
A	0071286	biological_process	cellular response to magnesium ion
A	0071320	biological_process	cellular response to cAMP
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071475	biological_process	cellular hyperosmotic salinity response
A	0071477	biological_process	cellular hypotonic salinity response
A	0097403	biological_process	cellular response to raffinose
A	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0003824	molecular_function	catalytic activity
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0006000	biological_process	fructose metabolic process
D	0006002	biological_process	fructose 6-phosphate metabolic process
D	0006094	biological_process	gluconeogenesis
D	0006111	biological_process	regulation of gluconeogenesis
D	0016208	molecular_function	AMP binding
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0030308	biological_process	negative regulation of cell growth
D	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
D	0031667	biological_process	response to nutrient levels
D	0032869	biological_process	cellular response to insulin stimulus
D	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
D	0042578	molecular_function	phosphoric ester hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0045820	biological_process	negative regulation of glycolytic process
D	0046580	biological_process	negative regulation of Ras protein signal transduction
D	0046872	molecular_function	metal ion binding
D	0048029	molecular_function	monosaccharide binding
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0070062	cellular_component	extracellular exosome
D	0071286	biological_process	cellular response to magnesium ion
D	0071320	biological_process	cellular response to cAMP
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	0071475	biological_process	cellular hyperosmotic salinity response
D	0071477	biological_process	cellular hypotonic salinity response
D	0097403	biological_process	cellular response to raffinose
D	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0003824	molecular_function	catalytic activity
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005975	biological_process	carbohydrate metabolic process
H	0006000	biological_process	fructose metabolic process
H	0006002	biological_process	fructose 6-phosphate metabolic process
H	0006094	biological_process	gluconeogenesis
H	0006111	biological_process	regulation of gluconeogenesis
H	0016208	molecular_function	AMP binding
H	0016787	molecular_function	hydrolase activity
H	0016791	molecular_function	phosphatase activity
H	0030308	biological_process	negative regulation of cell growth
H	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
H	0031667	biological_process	response to nutrient levels
H	0032869	biological_process	cellular response to insulin stimulus
H	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
H	0042578	molecular_function	phosphoric ester hydrolase activity
H	0042802	molecular_function	identical protein binding
H	0045820	biological_process	negative regulation of glycolytic process
H	0046580	biological_process	negative regulation of Ras protein signal transduction
H	0046872	molecular_function	metal ion binding
H	0048029	molecular_function	monosaccharide binding
H	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
H	0070062	cellular_component	extracellular exosome
H	0071286	biological_process	cellular response to magnesium ion
H	0071320	biological_process	cellular response to cAMP
H	0071466	biological_process	cellular response to xenobiotic stimulus
H	0071475	biological_process	cellular hyperosmotic salinity response
H	0071477	biological_process	cellular hypotonic salinity response
H	0097403	biological_process	cellular response to raffinose
H	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0003824	molecular_function	catalytic activity
L	0005515	molecular_function	protein binding
L	0005615	cellular_component	extracellular space
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005975	biological_process	carbohydrate metabolic process
L	0006000	biological_process	fructose metabolic process
L	0006002	biological_process	fructose 6-phosphate metabolic process
L	0006094	biological_process	gluconeogenesis
L	0006111	biological_process	regulation of gluconeogenesis
L	0016208	molecular_function	AMP binding
L	0016787	molecular_function	hydrolase activity
L	0016791	molecular_function	phosphatase activity
L	0030308	biological_process	negative regulation of cell growth
L	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
L	0031667	biological_process	response to nutrient levels
L	0032869	biological_process	cellular response to insulin stimulus
L	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
L	0042578	molecular_function	phosphoric ester hydrolase activity
L	0042802	molecular_function	identical protein binding
L	0045820	biological_process	negative regulation of glycolytic process
L	0046580	biological_process	negative regulation of Ras protein signal transduction
L	0046872	molecular_function	metal ion binding
L	0048029	molecular_function	monosaccharide binding
L	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
L	0070062	cellular_component	extracellular exosome
L	0071286	biological_process	cellular response to magnesium ion
L	0071320	biological_process	cellular response to cAMP
L	0071466	biological_process	cellular response to xenobiotic stimulus
L	0071475	biological_process	cellular hyperosmotic salinity response
L	0071477	biological_process	cellular hypotonic salinity response
L	0097403	biological_process	cellular response to raffinose
L	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE A74 A 701

Chain	Residue
A	VAL17
A	LEU30
A	THR31
A	LEU34
A	MET177
A	HOH517
L	GLY26
L	THR27
L	A741001
A	GLY21
A	ARG22
A	ALA24
A	ARG25
A	GLY26
A	THR27
A	GLY28
A	GLU29

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE A74 D 801

Chain	Residue
D	VAL17
D	GLY21
D	ALA24
D	ARG25
D	GLY26
D	THR27
D	GLY28
D	GLU29
D	LEU30
D	THR31
D	HOH510
H	GLY26
H	THR27
H	THR31
H	A74901

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE A74 H 901

Chain	Residue
D	GLY26
D	THR27
D	A74801
H	VAL17
H	GLY21
H	ARG22
H	ALA24
H	ARG25
H	GLY26
H	THR27
H	GLY28
H	GLU29
H	LEU30
H	THR31
H	HOH616

---

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE A74 L 1001

Chain	Residue
A	GLY26
A	THR27
A	GLY28
A	A74701
L	VAL17
L	GLY21
L	ARG22
L	ALA24
L	ARG25
L	GLY26
L	THR27
L	GLY28
L	GLU29
L	LEU30
L	THR31
L	MET177
L	HOH516

---

Functional Information from PROSITE/UniProt

site_id	PS00124
Number of Residues	13
Details	FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA

Chain	Residue	Details
A	GLY273-ALA285

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7809062","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00636","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PDB","id":"2FHY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9QXD6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QXD6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1eyi

Chain	Residue	Details
A	GLU98
A	ASP74

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1eyi

Chain	Residue	Details
D	GLU98
D	ASP74

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1eyi

Chain	Residue	Details
H	GLU98
H	ASP74

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1eyi

Chain	Residue	Details
L	GLU98
L	ASP74

---