2FDV
Microsomal P450 2A6 with the inhibitor N-Methyl(5-(pyridin-3-yl)furan-2-yl)methanamine bound
Summary for 2FDV
Entry DOI | 10.2210/pdb2fdv/pdb |
Related | 1Z10 1Z11 2FDU 2FDW 2FDY |
Descriptor | Cytochrome P450 2A6, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total) |
Functional Keywords | cyp2a6, p450 2a6, p450, monooxygenase, drug metabolizing enzyme, coumarin 7-hydroxylase, nicotine oxidase, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P11509 |
Total number of polymer chains | 4 |
Total formula weight | 222820.19 |
Authors | Yano, J.K.,Stout, C.D.,Johnson, E.F. (deposition date: 2005-12-14, release date: 2006-11-28, Last modification date: 2023-08-30) |
Primary citation | Yano, J.K.,Denton, T.T.,Cerny, M.A.,Zhang, X.,Johnson, E.F.,Cashman, J.R. Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization. J.Med.Chem., 49:6987-7001, 2006 Cited by PubMed: 17125252DOI: 10.1021/jm060519r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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