2FD6

Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A

2FD6 の概要

• エントリーDOI: 10.2210/pdb2fd6/pdb
• 関連するPDBエントリー: 2fat
• 分子名称: Urokinase-type plasminogen activator, TRIETHYLENE GLYCOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose, ... (13 entities in total)
• 機能のキーワード: upar, atf, atn-615 antibody, fab, ternary complex, immune system, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 92831.71

構造登録者

Huang, M.,Huai, Q.,Li, Y. (登録日: 2005-12-13, 公開日: 2006-02-21, 最終更新日: 2024-11-20)

主引用文献

Huai, Q.,Mazar, A.P.,Kuo, A.,Parry, G.C.,Shaw, D.E.,Callahan, J.,Li, Y.,Yuan, C.,Bian, C.,Chen, L.,Furie, B.,Furie, B.C.,Cines, D.B.,Huang, M.
Structure of human urokinase plasminogen activator in complex with its receptor
Science, 311:656-659, 2006

PubMed Abstract: The urokinase plasminogen activator binds to its cellular receptor with high affinity and initiates signaling cascades that are implicated in pathological processes including tumor growth, metastasis, and inflammation. We report the crystal structure at 1.9 angstroms of the urokinase receptor complexed with the urokinase amino-terminal fragment and an antibody against the receptor. The three domains of urokinase receptor form a concave shape with a central cone-shaped cavity where the urokinase fragment inserts. The structure provides insight into the flexibility of the urokinase receptor that enables its interaction with a wide variety of ligands and a basis for the design of urokinase-urokinase receptor antagonists.

PubMed: 16456079
DOI: 10.1126/science.1121143

実験手法

X-RAY DIFFRACTION (1.9 Å)