2F98

Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.

Summary for 2F98

Entry DOI	10.2210/pdb2f98/pdb
Related	2F99
Descriptor	Aklanonic Acid methyl Ester Cyclase, AknH, SULFATE ION, METHYL 5,7-DIHYDROXY-2-METHYL-4,6,11-TRIOXO-3,4,6,11-TETRAHYDROTETRACENE-1-CARBOXYLATE, ... (4 entities in total)
Functional Keywords	anthracycline, polyketide cyclase, stereoselectivity, aklavinone, biosynthetic protein
Biological source	Streptomyces galilaeus
Total number of polymer chains	4
Total formula weight	73702.16
Authors	Kallio, P.,Sultana, A.,Neimi, J.,Mantsala, P.,Schneider, G. (deposition date: 2005-12-05, release date: 2006-02-14, Last modification date: 2023-08-30)
Primary citation	Kallio, P.,Sultana, A.,Niemi, J.,Schneider, G. Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity. J.Mol.Biol., 357:210-220, 2006 Cited by PubMed: 16414075 DOI: 10.1016/j.jmb.2005.12.064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation