2F99
Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.
Summary for 2F99
Entry DOI | 10.2210/pdb2f99/pdb |
Related | 2F98 |
Descriptor | Aklanonic Acid methyl Ester Cyclase, AknH, SULFATE ION, {3-[(1R,3S)-1,3-DIHYDROXYPENTYL]-4,5,9,10-TETRAHYDROXY-2-ANTHRYL}ACETATE, ... (4 entities in total) |
Functional Keywords | anthracycline, polyketide cyclase, stereoselectivity, aklavinone, biosynthetic protein |
Biological source | Streptomyces galilaeus |
Total number of polymer chains | 4 |
Total formula weight | 74518.90 |
Authors | Kallio, P.,Sultana, A.,Neimi, J.,Mantsala, P.,Schneider, G. (deposition date: 2005-12-05, release date: 2006-02-14, Last modification date: 2023-08-30) |
Primary citation | Kallio, P.,Sultana, A.,Niemi, J.,Schneider, G. Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity. J.Mol.Biol., 357:210-220, 2006 Cited by PubMed: 16414075DOI: 10.1016/j.jmb.2005.12.064 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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