2F98
Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Aklanonic Acid methyl Ester Cyclase, AknH | polymer | 153 | 17951.1 | 4 | GenBank (7800671) Pfam (PF07366) UniProt (by SIFTS) (O52646) | Streptomyces galilaeus | |
| 2 | E, G, I, K (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | F, H, J, L (A, B, C, D) | METHYL 5,7-DIHYDROXY-2-METHYL-4,6,11-TRIOXO-3,4,6,11-TETRAHYDROTETRACENE-1-CARBOXYLATE | non-polymer | 378.3 | 4 | Chemie (NGV) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 245 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 144 (GenBank: 7800671)
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | cloning artifact |
| Ala -7 | - | cloning artifact |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| Arg 1 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 71804.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1897.6 | |
| All* | Total formula weight | 73702.2 |
