2F8C

Crystal structure of FPPS in complex with Zoledronate

Summary for 2F8C

Entry DOI	10.2210/pdb2f8c/pdb
Related	2F7M 2F89 2F92 2F94 2F9K
Descriptor	Farnesyl Diphosphate Synthase, PHOSPHATE ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	mevalonate pathway, ; isoprene biosynthesis; cholesterol biosynthesis; bisphosphonate inhibitor, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	40623.83
Authors	Rondeau, J.-M.,Bitsch, F.,Bourgier, E.,Geiser, M.,Hemmig, R.,Kroemer, M.,Lehmann, S.,Ramage, P.,Rieffel, S.,Strauss, A.,Green, J.R.,Jahnke, W. (deposition date: 2005-12-02, release date: 2006-02-28, Last modification date: 2024-02-14)
Primary citation	Rondeau, J.M.,Bitsch, F.,Bourgier, E.,Geiser, M.,Hemmig, R.,Kroemer, M.,Lehmann, S.,Ramage, P.,Rieffel, S.,Strauss, A.,Green, J.R.,Jahnke, W. Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs. Chemmedchem, 1:267-273, 2006 Cited by PubMed: 16892359 DOI: 10.1002/cmdc.200500059 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation