2F2C

X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol

Summary for 2F2C

• Entry DOI: 10.2210/pdb2f2c/pdb
• Related: 2EUF
• Descriptor: Cyclin homolog, Cell division protein kinase 6, SULFATE ION, ... (5 entities in total)
• Functional Keywords: small molecule inhibitor bound between n-terminal and c-terminal domain of kinase, cell cycle-transferase complex, cell cycle/transferase
• Biological source: Herpesvirus saimiri (strain 11); More
• Cellular location: Cytoplasm: Q00534
• Total number of polymer chains: 2
• Total formula weight: 64309.85

Authors

Schulze-Gahmen, U.,Lu, H. (deposition date: 2005-11-16, release date: 2006-06-13, Last modification date: 2024-02-14)

• Primary citation: Lu, H.,Schulze-Gahmen, U.; Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.; J.Med.Chem., 49:3826-3831, 2006; PubMed: 16789739; DOI: 10.1021/jm0600388

Experimental method

X-RAY DIFFRACTION (2.8 Å)