2F27
Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor
Summary for 2F27
Entry DOI | 10.2210/pdb2f27/pdb |
Related | 1SNT 1SO7 1VCU 2F0Z 2F10 2F11 2F12 2F13 2F24 2F25 2F26 2F28 2F29 |
Descriptor | Sialidase 2, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | sialidase, neuraminidase, ganglioside, drug design, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 86374.93 |
Authors | Chavas, L.M.G.,Kato, R.,Fusi, P.,Tringali, C.,Venerando, B.,Tettamanti, G.,Monti, E.,Wakatsuki, S. (deposition date: 2005-11-15, release date: 2006-11-21, Last modification date: 2023-10-25) |
Primary citation | Chavas, L.M.G.,Kato, R.,Fusi, P.,Tringali, C.,Venerando, B.,Tettamanti, G.,Monti, E.,Wakatsuki, S. Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor To be Published, |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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