2F27

Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004308	molecular_function	exo-alpha-sialidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005829	cellular_component	cytosol
A	0006516	biological_process	glycoprotein catabolic process
A	0006629	biological_process	lipid metabolic process
A	0006689	biological_process	ganglioside catabolic process
A	0009313	biological_process	oligosaccharide catabolic process
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0046479	biological_process	glycosphingolipid catabolic process
A	1902494	cellular_component	catalytic complex
B	0004308	molecular_function	exo-alpha-sialidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005829	cellular_component	cytosol
B	0006516	biological_process	glycoprotein catabolic process
B	0006629	biological_process	lipid metabolic process
B	0006689	biological_process	ganglioside catabolic process
B	0009313	biological_process	oligosaccharide catabolic process
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0046479	biological_process	glycosphingolipid catabolic process
B	1902494	cellular_component	catalytic complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Repeat: {"description":"BNR 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	22
Details	Repeat: {"description":"BNR 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Motif: {"description":"FRIP motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"22228546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Active site: {"description":"Nucleophile"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	14
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1euu

Chain	Residue	Details
A	TYR334
A	ASP46
A	GLU218

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1euu

Chain	Residue	Details
B	TYR334
B	ASP46
B	GLU218

---