2F27
Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006516 | biological_process | glycoprotein catabolic process |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0009313 | biological_process | oligosaccharide catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0046479 | biological_process | glycosphingolipid catabolic process |
| A | 1902494 | cellular_component | catalytic complex |
| B | 0004308 | molecular_function | exo-alpha-sialidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005764 | cellular_component | lysosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0006516 | biological_process | glycoprotein catabolic process |
| B | 0006689 | biological_process | ganglioside catabolic process |
| B | 0009313 | biological_process | oligosaccharide catabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0046479 | biological_process | glycosphingolipid catabolic process |
| B | 1902494 | cellular_component | catalytic complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Repeat: {"description":"BNR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Repeat: {"description":"BNR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Motif: {"description":"FRIP motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"15501818","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22228546","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"15501818","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22228546","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15501818","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24591206","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1VCU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NCS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1euu |
| Chain | Residue | Details |
| A | TYR334 | |
| A | ASP46 | |
| A | GLU218 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1euu |
| Chain | Residue | Details |
| B | TYR334 | |
| B | ASP46 | |
| B | GLU218 |
