2F27
Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Sialidase 2 | polymer | 382 | 42419.6 | 2 | UniProt (Q9Y3R4) Pfam (PF13088) | Homo sapiens (human) | Neu2, Cytosolic sialidase, N-acetyl-alpha- neuraminidase 2 |
| 2 | C, F (A, B) | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID | non-polymer | 291.3 | 2 | Chemie (DAN) PubChem (1553) PubChem (65309) PubChem (196123) PubChem (440392) PubChem (44299597) PubChem (44305374) PubChem (44314809) PubChem (44353094) PubChem (44387099) PubChem (44629965) PubChem (492456) PubChem (49819354) PubChem (57673682) PubChem (50986297) PubChem (68019401) PubChem (71299570) PubChem (71312796) PubChem (93616863) PubChem (13728878) PubChem (101008065) PubChem (5329058) PubChem (102094437) PubChem (132002898) PubChem (15956564) PubChem (133688885) | |||
| 3 | D, E, G, H (A, B) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 4 | Chemie (EPE) PubChem (23831) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 275 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 380 (UniProt: Q9Y3R4)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
| Gln 111 | Glu 111 | engineered mutation |
| Glu 112 | Gln 112 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84839.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1535.7 | |
| All* | Total formula weight | 86374.9 |
