1VCU
Structure of the human cytosolic sialidase Neu2 in complex with the inhibitor DANA
Summary for 1VCU
Entry DOI | 10.2210/pdb1vcu/pdb |
Related | 1SNT 1SO7 |
Descriptor | Sialidase 2, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | sialidase, neuraminidase, ganglioside, dana, sialic acid, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 86374.93 |
Authors | Chavas, L.M.G.,Fusi, P.,Tringali, C.,Venerando, B.,Tettamanti, G.,Kato, R.,Monti, E.,Wakatsuki, S. (deposition date: 2004-03-12, release date: 2004-11-02, Last modification date: 2023-10-25) |
Primary citation | Chavas, L.M.G.,Tringali, C.,Fusi, P.,Venerando, B.,Tettamanti, G.,Kato, R.,Monti, E.,Wakatsuki, S. Crystal Structure of the Human Cytosolic Sialidase Neu2: EVIDENCE FOR THE DYNAMIC NATURE OF SUBSTRATE RECOGNITION J.Biol.Chem., 280:469-475, 2005 Cited by PubMed: 15501818DOI: 10.1074/jbc.M411506200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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