1VCU
Structure of the human cytosolic sialidase Neu2 in complex with the inhibitor DANA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Sialidase 2 | polymer | 382 | 42419.6 | 2 | UniProt (Q9Y3R4) Pfam (PF13088) | Homo sapiens (human) | Neu2, Cytosolic sialidase, N-acetyl-alpha- neuraminidase 2 |
| 2 | C, F (A, B) | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID | non-polymer | 291.3 | 2 | Chemie (DAN) PubChem (1553) PubChem (65309) PubChem (196123) PubChem (440392) PubChem (44299597) PubChem (44305374) PubChem (44314809) PubChem (44353094) PubChem (44387099) PubChem (44629965) PubChem (492456) PubChem (49819354) PubChem (57673682) PubChem (50986297) PubChem (68019401) PubChem (71299570) PubChem (71312796) PubChem (93616863) PubChem (13728878) PubChem (101008065) PubChem (5329058) PubChem (102094437) PubChem (132002898) PubChem (15956564) PubChem (133688885) | |||
| 3 | D, E, G, H (A, B) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 4 | Chemie (EPE) PubChem (23831) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 380 (UniProt: Q9Y3R4)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84839.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1535.7 | |
| All* | Total formula weight | 86374.9 |
