2F25

Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor

Summary for 2F25

• Entry DOI: 10.2210/pdb2f25/pdb
• Related: 1SNT 1SO7 1VCU 2F0Z 2F10 2F11 2F12 2F13 2F24 2F26 2F27 2F28 2F29
• Descriptor: Sialidase 2, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: sialidase, neuraminidase, ganglioside, drug design, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 86372.95

Authors

Chavas, L.M.G.,Kato, R.,Fusi, P.,Tringali, C.,Venerando, B.,Tettamanti, G.,Monti, E.,Wakatsuki, S. (deposition date: 2005-11-15, release date: 2006-11-21, Last modification date: 2023-10-25)

• Primary citation: Chavas, L.M.G.,Kato, R.,Fusi, P.,Tringali, C.,Venerando, B.,Tettamanti, G.,Monti, E.,Wakatsuki, S.; Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor; To be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)