2F25
Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Sialidase 2 | polymer | 382 | 42418.6 | 2 | UniProt (Q9Y3R4) Pfam (PF13088) | Homo sapiens (human) | Neu2, Cytosolic sialidase, N-acetyl-alpha- neuraminidase 2 |
| 2 | C, F (A, B) | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID | non-polymer | 291.3 | 2 | Chemie (DAN) | |||
| 3 | D, E, G, H (A, B) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 4 | Chemie (EPE) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 460 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 380 (UniProt: Q9Y3R4)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
| Gln 111 | Glu 111 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84837.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1535.7 | |
| All* | Total formula weight | 86372.9 |
