2F16
Crystal structure of the yeast 20S proteasome in complex with bortezomib
Summary for 2F16
Entry DOI | 10.2210/pdb2f16/pdb |
Related | 1PMA 1RYP |
Descriptor | Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total) |
Functional Keywords | beta-sandwich flanked by helices, complex structure covalently bound to the synthetic inihibtor bortezomib, hydrolase |
Biological source | Saccharomyces cerevisiae (baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 706511.66 |
Authors | Groll, M. (deposition date: 2005-11-14, release date: 2006-03-21, Last modification date: 2023-08-23) |
Primary citation | Groll, M.,Berkers, C.R.,Ploegh, H.L.,Ovaa, H. Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome. Structure, 14:451-456, 2006 Cited by PubMed: 16531229DOI: 10.1016/j.str.2005.11.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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