2F11

Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor

Summary for 2F11

• Entry DOI: 10.2210/pdb2f11/pdb
• Related: 1SN7 1SO7 1VCU 2F0Z 2F10 2F12 2F13 2F24 2F25 2F26 2F27 2F28 2F29
• Descriptor: Sialidase 2, PHOSPHATE ION, 2-methylpropyl 2-acetamido-2,4-dideoxy-alpha-L-threo-hex-4-enopyranosiduronic acid, ... (4 entities in total)
• Functional Keywords: sialidase, neuraminidase, influenza virus, drug design, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 42787.85

Authors

Chavas, L.M.G.,Kato, R.,Mann, M.C.,Thomson, R.J.,Dyason, J.C.,von Itzstein, M.,Fusi, P.,Tringali, C.,Venerando, B.,Tettamanti, G.,Monti, E.,Wakatsuki, S. (deposition date: 2005-11-14, release date: 2006-11-21, Last modification date: 2023-10-25)

• Primary citation: Chavas, L.M.G.,Kato, R.,Mann, M.C.,Thomson, R.J.,Dyason, J.C.,von Itzstein, M.,Fusi, P.,Tringali, C.,Venerando, B.,Tettamanti, G.,Monti, E.,Wakatsuki, S.; Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor; To be Published,

Experimental method

X-RAY DIFFRACTION (2.57 Å)