2F11
Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Sialidase 2 | polymer | 382 | 42419.6 | 1 | UniProt (Q9Y3R4) Pfam (PF13088) In PDB | Homo sapiens (human) | Neu2, Cytosolic sialidase, N-acetyl-alpha- neuraminidase 2 |
| 2 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 3 | A | 2-methylpropyl 2-acetamido-2,4-dideoxy-alpha-L-threo-hex-4-enopyranosiduronic acid | non-polymer | 273.3 | 1 | Chemie (IEM) | |||
| 4 | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A: 1 - 380 (UniProt: Q9Y3R4)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42419.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 368.3 | |
| All* | Total formula weight | 42787.9 |
