2EXL
GRP94 N-terminal Domain bound to geldanamycin
Summary for 2EXL
Entry DOI | 10.2210/pdb2exl/pdb |
Related | 1QY5 1TBW 1TC6 1U20 1YT1 2ESA |
Descriptor | Endoplasmin, GELDANAMYCIN, TETRAETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | grp94, gp96, hsp90, bergerat fold, chaperone, endoplasmic reticulum, geldanamycin, 17-aag |
Biological source | Canis lupus familiaris (dog) More |
Cellular location | Endoplasmic reticulum lumen: P41148 |
Total number of polymer chains | 2 |
Total formula weight | 55164.48 |
Authors | Reardon, P.N.,Immormino, R.M.,Gewirth, D.T. (deposition date: 2005-11-08, release date: 2006-10-24, Last modification date: 2023-08-23) |
Primary citation | Immormino, R.M.,Metzger, L.E.,Reardon, P.N.,Dollins, D.E.,Blagg, B.S.,Gewirth, D.T. Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design. J.Mol.Biol., 388:1033-1042, 2009 Cited by PubMed: 19361515DOI: 10.1016/j.jmb.2009.03.071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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