2EXL
GRP94 N-terminal Domain bound to geldanamycin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006457 | biological_process | protein folding |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0051082 | molecular_function | unfolded protein binding |
| A | 0140662 | molecular_function | ATP-dependent protein folding chaperone |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006457 | biological_process | protein folding |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0051082 | molecular_function | unfolded protein binding |
| B | 0140662 | molecular_function | ATP-dependent protein folding chaperone |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GDM A 301 |
| Chain | Residue |
| A | ASN107 |
| A | VAL197 |
| A | GLY198 |
| A | PHE199 |
| A | THR245 |
| A | HOH504 |
| A | HOH505 |
| A | HOH558 |
| A | HOH592 |
| A | ALA108 |
| A | ASP110 |
| A | LYS114 |
| A | ASP149 |
| A | MET154 |
| A | ASN162 |
| A | LEU163 |
| A | GLY196 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GDM B 302 |
| Chain | Residue |
| B | ASN107 |
| B | ALA108 |
| B | ASP110 |
| B | ALA111 |
| B | LYS114 |
| B | ASP149 |
| B | MET154 |
| B | ASN162 |
| B | LEU163 |
| B | GLY196 |
| B | VAL197 |
| B | GLY198 |
| B | PHE199 |
| B | HOH512 |
| B | HOH513 |
| B | HOH526 |
| B | HOH541 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PG4 A 501 |
| Chain | Residue |
| A | THR212 |
| A | ARG237 |
| A | THR240 |
| A | THR248 |
| A | PG4502 |
| A | HOH507 |
| A | HOH518 |
| A | HOH574 |
| A | HOH575 |
| B | LEU117 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 A 502 |
| Chain | Residue |
| A | LYS137 |
| A | HIS146 |
| A | THR148 |
| A | TRP282 |
| A | PG4501 |
| A | HOH503 |
| A | HOH601 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PG4 B 508 |
| Chain | Residue |
| A | LEU117 |
| A | HOH598 |
| B | LYS142 |
| B | THR212 |
| B | ARG237 |
| B | THR248 |
| B | PG4406 |
| B | HOH539 |
| B | HOH570 |
| B | HOH601 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PG4 B 406 |
| Chain | Residue |
| B | LYS137 |
| B | HIS146 |
| B | TRP282 |
| B | PG4508 |
| B | HOH599 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1PE A 409 |
| Chain | Residue |
| A | ASN83 |
| A | LYS87 |
| A | SER227 |
| A | HOH602 |
| B | ASN83 |
| B | LYS87 |
| B | ILE90 |
| B | HOH523 |
Functional Information from PROSITE/UniProt
| site_id | PS00298 |
| Number of Residues | 10 |
| Details | HSP90 Heat shock hsp90 proteins family signature. YkNKEIFLRE |
| Chain | Residue | Details |
| A | TYR94-GLU103 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15292259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15951571","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17936703","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TC6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O1V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15292259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15951571","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17936703","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TC6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O1V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15292259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15951571","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17936703","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TC6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O1V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
