6D28
Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with the specific ligand NECA
Replaces: 1QY5Summary for 6D28
Entry DOI | 10.2210/pdb6d28/pdb |
Descriptor | Endoplasmin, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE, ... (4 entities in total) |
Functional Keywords | hsp90, grp94, neca, inhibitor, chaperone |
Biological source | Canis lupus familiaris (Dog) |
Total number of polymer chains | 1 |
Total formula weight | 31498.26 |
Authors | Soldano, K.L.,Jivan, A.,Nicchitta, C.V.,Gewirth, D.T. (deposition date: 2018-04-13, release date: 2018-05-16, Last modification date: 2024-03-13) |
Primary citation | Soldano, K.L.,Jivan, A.,Nicchitta, C.V.,Gewirth, D.T. Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation. J. Biol. Chem., 278:48330-48338, 2003 Cited by PubMed: 12970348DOI: 10.1074/jbc.M308661200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report