2EXB

Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, complexed with FLOMOX

Summary for 2EXB

• Entry DOI: 10.2210/pdb2exb/pdb
• Related: 2EX2 2EX6 2EX8 2EX9 2EXA
• Descriptor: Penicillin-binding protein 4, 2,2-dimethylpropanoyloxymethyl (2R)-5-(aminocarbonyloxymethyl)-2-[(1R)-1-[[(Z)-2-(2-azanyl-1,3-thiazol-4-yl)pent-2-enoyl]amino]-2-oxidanylidene-ethyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate, GLYCEROL, ... (4 entities in total)
• Functional Keywords: penicillin-binding protein, penicillin, cephem, penem, flomox, d-alanyl-d-alanine-carboxypeptidase, d-alanyl-d-alanine-endopeptidase, hydrolase
• Biological source: Escherichia coli
• Cellular location: Periplasm : P24228
• Total number of polymer chains: 1
• Total formula weight: 50458.46

Authors

Kishida, H.,Unzai, S.,Roper, D.I.,Lloyd, A.,Park, S.-Y.,Tame, J.R.H. (deposition date: 2005-11-08, release date: 2006-06-13, Last modification date: 2016-10-19)

• Primary citation: Kishida, H.,Unzai, S.,Roper, D.I.,Lloyd, A.,Park, S.-Y.,Tame, J.R.H.; Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics; Biochemistry, 45:783-792, 2006; PubMed: 16411754; DOI: 10.1021/bi051533t

Experimental method

X-RAY DIFFRACTION (1.75 Å)