2EX6

Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, complexed with ampicillin

Summary for 2EX6

• Entry DOI: 10.2210/pdb2ex6/pdb
• Related: 2EX2 2EX8 2EX9 2EXA 2EXB
• Descriptor: Penicillin-binding protein 4, (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, GLYCEROL, ... (4 entities in total)
• Functional Keywords: penicillin-binding protein, ampicillin, cephem, penem, d-alanyl-d-alanine-carboxypeptidase, d-alanyl-d-alanine-endopeptidase, hydrolase
• Biological source: Escherichia coli
• Cellular location: Periplasm : P24228
• Total number of polymer chains: 1
• Total formula weight: 50240.23

Authors

Kishida, H.,Unzai, S.,Roper, D.I.,Lloyd, A.,Park, S.-Y.,Tame, J.R.H. (deposition date: 2005-11-08, release date: 2006-06-13, Last modification date: 2016-10-19)

• Primary citation: Kishida, H.,Unzai, S.,Roper, D.I.,Lloyd, A.,Park, S.-Y.,Tame, J.R.H.; Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics; Biochemistry, 45:783-792, 2006; PubMed: 16411754; DOI: 10.1021/bi051533t

Experimental method

X-RAY DIFFRACTION (1.6 Å)