2E95
S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-675
Summary for 2E95
Entry DOI | 10.2210/pdb2e95/pdb |
Related | 2DH4 2E8T 2E8U 2E8V 2E8W 2E8X 2E90 2E91 2E92 2E93 2E94 2E96 2E97 |
Descriptor | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 1-HYDROXY-2-[3'-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC ACID, ... (4 entities in total) |
Functional Keywords | prenyltransferase, farnesyl pyrophosphate, bisphosphonate, transferase |
Biological source | Saccharomyces cerevisiae (baker's yeast) |
Cellular location | Cytoplasm (By similarity): Q12051 |
Total number of polymer chains | 2 |
Total formula weight | 79822.24 |
Authors | Guo, R.T.,Cao, R.,Ko, T.P.,Jeng, W.Y.,Chang, T.H.,Chen, C.K.-M.,Liang, P.H.,Oldfield, E.,Wang, A.H.-J. (deposition date: 2007-01-24, release date: 2007-06-12, Last modification date: 2023-10-25) |
Primary citation | Guo, R.T.,Cao, R.,Liang, P.H.,Ko, T.P.,Chang, T.H.,Hudock, M.P.,Jeng, W.Y.,Chen, C.K.-M.,Zhang, Y.,Song, Y.,Kuo, C.J.,Yin, F.,Oldfield, E.,Wang, A.H.-J. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104:10022-10027, 2007 Cited by PubMed: 17535895DOI: 10.1073/pnas.0702254104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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