2DVS

Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide

2DVS の概要

• エントリーDOI: 10.2210/pdb2dvs/pdb
• 関連するPDBエントリー: 1X0J 2DVQ 2DVR
• 分子名称: bromodomain-containing protein 2, histone H4 (3 entities in total)
• 機能のキーワード: alpha-helical domain, bromodomain, binds to acetylated histones, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus (By similarity): P25440
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 47107.69

構造登録者

Nakamura, Y.,Umehara, T.,Shirouzu, M.,Padmanabhan, B.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2006-08-01, 公開日: 2007-08-07, 最終更新日: 2024-04-03)

• 主引用文献: Umehara, T.,Nakamura, Y.,Jang, M.K.,Nakano, K.,Tanaka, A.,Ozato, K.,Padmanabhan, B.,Yokoyama, S.; Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.; J.Biol.Chem., 285:7610-7618, 2010; PubMed: 20048151; DOI: 10.1074/jbc.M109.062422

実験手法

X-RAY DIFFRACTION (2.04 Å)