2DM6

Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex

2DM6 の概要

• エントリーDOI: 10.2210/pdb2dm6/pdb
• 関連するPDBエントリー: 1V3T 1V3U 1V3V
• 分子名称: NADP-dependent leukotriene B4 12-hydroxydehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, INDOMETHACIN, ... (5 entities in total)
• 機能のキーワード: nad(p)-binding rossmann-fold domains, riken structural genomics/proteomics initiative, rsgi, structural genomics, oxidoreductase
• 由来する生物種: Cavia porcellus (domestic guinea pig)
• 細胞内の位置: Cytoplasm : Q9EQZ5
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 74471.76

構造登録者

Hori, T.,Ishijima, J.,Yokomizo, T.,Ago, H.,Shimizu, T.,Miyano, M.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2006-04-20, 公開日: 2006-11-28, 最終更新日: 2017-10-11)

• 主引用文献: Hori, T.,Ishijima, J.,Yokomizo, T.,Ago, H.,Shimizu, T.,Miyano, M.; Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy; J.Biochem.(Tokyo), 140:457-466, 2006; PubMed: 16916844; DOI: 10.1093/jb/mvj176

実験手法

X-RAY DIFFRACTION (2 Å)