2CN0

Complex of Recombinant Human Thrombin with a Designed Inhibitor

Summary for 2CN0

Entry DOI	10.2210/pdb2cn0/pdb
Related PRD ID	PRD_000481
Descriptor	PROTHROMBIN PRECURSOR, HIRUDIN IIA, 4-(1R,3AS,4R,8AS,8BR)-[1-DIFLUOROMETHYL-2-(4-FLUOROBENZYL)-3-OXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZAMIDINE, ... (7 entities in total)
Functional Keywords	acute phase, blood coagulation, calcium-binding, glycoprotein, hydrolase, serine protease, serine protease inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Secreted, extracellular space: P00734 P00734 Secreted: P28503
Total number of polymer chains	3
Total formula weight	34801.78
Authors	Hoffmann-Roder, A.,Schweizer, E.,Egger, J.,Seiler, P.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F. (deposition date: 2006-05-17, release date: 2006-11-06, Last modification date: 2023-12-13)
Primary citation	Hoffmann-Roder, A.,Schweizer, E.,Egger, J.,Seiler, P.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F. Mapping the Fluorophilicity of a Hydrophobic Pocket: Synthesis and Biological Evaluation of Tricyclic Thrombin Inhibitors Directing Fluorinated Alkyl Groups Into the P Pocket Chemmedchem, 1:1205-, 2006 Cited by PubMed: 17001711 DOI: 10.1002/CMDC.200600124 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation