2CN0
Complex of Recombinant Human Thrombin with a Designed Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | PROTHROMBIN PRECURSOR | polymer | 257 | 29594.1 | 1 | UniProt (P00734) Pfam (PF00089) | HOMO SAPIENS (HUMAN) | COAGULATION FACTOR II, THROMBIN |
| 2 | B (I) | HIRUDIN IIA | polymer | 11 | 1396.5 | 1 | UniProt (P28503) UniProt (by SIFTS) (P09945) BIRD (PRD_000481) | HIRUDO MEDICINALIS | |
| 3 | C (L) | PROTHROMBIN PRECURSOR | polymer | 28 | 3303.7 | 1 | UniProt (P00734) Pfam (PF09396) | HOMO SAPIENS (HUMAN) | COAGULATION FACTOR II, THROMBIN |
| 4 | D (H) | 4-(1R,3AS,4R,8AS,8BR)-[1-DIFLUOROMETHYL-2-(4-FLUOROBENZYL)-3-OXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZAMIDINE | non-polymer | 444.5 | 1 | Chemie (F25) | |||
| 5 | E (H) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | F (H) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | G, H, I (H, I, L) | water | water | 18.0 | 397 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 34294.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 507.6 | |
| All* | Total formula weight | 34801.8 |
