2CFI

The hydrolase domain of human 10-FTHFD in complex with 6- formyltetrahydropterin

Summary for 2CFI

Related2BW0 2CQ8
Descriptor10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE, SULFATE ION, 6-FORMYLTETRAHYDROPTERIN, ... (4 entities in total)
Functional Keywordstetrahydrofolate, folate binding, nadp, one-carbon metabolism, oxidoreductase, phosphopantetheine
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm O75891
Total number of polymer chains1
Total molecular weight36866.86
Authors
Primary citation
Kursula, P.,Schuler, H.,Flodin, S.,Nilsson-Ehle, P.,Ogg, D.J.,Savitsky, P.,Nordlund, P.,Stenmark, P.
Structures of the Hydrolase Domain of Human 10-Formyltetrahydrofolate Dehydrogenase and its Complex with a Substrate Analogue.
Acta Crystallogr.,Sect.D, 62:1294-, 2006
PubMed: 17057331 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444906026849
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24460.6%3.5%15.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution