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2CFI

The hydrolase domain of human 10-FTHFD in complex with 6- formyltetrahydropterin

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0009058biological_processbiosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A1308
ChainResidue
AARG112
ALYS128
ALYS129

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A1309
ChainResidue
AARG60
APHE89
APRO264
AGLY265

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A1310
ChainResidue
AHOH2300
AHOH2301
AHOH2302
AARG112
AGLY197

site_idAC4
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ZZZ A1311
ChainResidue
ACYS86
ASER87
AGLN88
APHE89
AILE90
AILE95
AILE104
APHE135
AASP138
AGLY140
AASP142
AHOH2136

Functional Information from PROSITE/UniProt
site_idPS00373
Number of Residues24
DetailsGART Phosphoribosylglycinamide formyltransferase active site. GfSIfWAdDgLDtGdlLlqkeceV
ChainResidueDetails
AGLY131-VAL154

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P28037","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17057331","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2CFI","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsSite: {"description":"Essential for catalytic activity","evidences":[{"source":"UniProtKB","id":"P28037","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8R0Y6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1c2t
ChainResidueDetails
AASP142
AILE104
ASER133
AHIS106

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1c2t
ChainResidueDetails
AASP142
AILE104
AHIS106

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1c2t
ChainResidueDetails
AASP142
AHIS106

243083

PDB entries from 2025-10-15

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