2CFI

The hydrolase domain of human 10-FTHFD in complex with 6- formyltetrahydropterin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE	polymer	329	36383.5	1	UniProt (O75891) Pfam (PF00551) Pfam (PF02911)	HOMO SAPIENS (HUMAN)	10-FTHFDH, ALDEHYDE DEHYDROGENASE 1 FAMILY MEMBER L1
2	B, C, D (A)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
3	E (A)	6-FORMYLTETRAHYDROPTERIN	non-polymer		195.2	1	Chemie (ZZZ)
4	F (A)	water	water		18.0	303	Chemie (HOH)

Sequence modifications

A: 1 - 307 (UniProt: O75891)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36383.5
Non-Polymers*	Number of molecules	4
	Total formula weight	483.4
All*	Total formula weight	36866.9

*Water molecules are not included.