2C3I
CRYSTAL STRUCTURE OF HUMAN PIM1 IN COMPLEX WITH IMIDAZOPYRIDAZIN I
Summary for 2C3I
Entry DOI | 10.2210/pdb2c3i/pdb |
Related | 1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK |
Descriptor | PIMTIDE, PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, ... (4 entities in total) |
Functional Keywords | transferase-peptide complex, complex transferase-peptide, pim1, kinase, cancer, leukemia, atp-binding, nuclear protein, nucleotide-binding, phosphorylation, proto- oncogene, serine/threonine-protein kinase, transferase, transferase/peptide |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 2 |
Total formula weight | 36937.13 |
Authors | Philippakopoulos, P.,Knapp, S.,Debreczeni, J.,Bullock, A.,von Delft, F.,Sundstrom, M.,Arrowsmith, C.,Edwards, A.,Guo, K.,Weigelt, J. (deposition date: 2005-10-07, release date: 2005-11-01, Last modification date: 2023-12-13) |
Primary citation | Pogacic, V.,Bullock, A.N.,Fedorov, O.,Filippakopoulos, P.,Gasser, C.,Biondi, A.,Meyer-Monard, S.,Knapp, S.,Schwaller, J. Structural Analysis Identifies Imidazo[1,2- B]Pyridazines as Pim Kinase Inhibitors with in Vitro Antileukemic Activity. Cancer Res., 67:6916-, 2007 Cited by PubMed: 17638903DOI: 10.1158/0008-5472.CAN-07-0320 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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