2BUB

Crystal Structure Of Human Dipeptidyl Peptidase IV (CD26) in Complex with a Reversed Amide Inhibitor

2BUB の概要

• エントリーDOI: 10.2210/pdb2bub/pdb
• 関連するPDBエントリー: 1J2E 1N1M 1NU6 1NU8 1PFQ 1R9M 1R9N 1RWQ 1TK3 1TKR 1U8E 1W1I 1WCY 1X70 2AJL 2BGN 2BGR
• 分子名称: DIPEPTIDYL PEPTIDASE 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDE, ... (4 entities in total)
• 機能のキーワード: hydrolase/inhibitor, complex (hydrolase-inhibitor), dpp-iv, diabetes mellitus, drug design, hydrolase, serine protease, aminopeptidase, glycoprotein, protease, signal-anchor, transmembrane, complex, hydrolase-inhibitor complex
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 171461.82

構造登録者

Nordhoff, S.,Cerezo-Galvez, S.,Feurer, A.,Hill, O.,Matassa, V.G.,Metz, G.,Rummey, C.,Thiemann, M.,Edwards, P.J. (登録日: 2005-06-09, 公開日: 2006-01-23, 最終更新日: 2020-07-29)

• 主引用文献: Nordhoff, S.,Cerezo-Galvez, S.,Feurer, A.,Hill, O.,Matassa, V.G.,Metz, G.,Rummey, C.,Thiemann, M.,Edwards, P.J.; The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors.; Bioorg. Med. Chem. Lett., 16:1744-1748, 2006; PubMed: 16376544; DOI: 10.1016/j.bmcl.2005.11.103

実験手法

X-RAY DIFFRACTION (2.66 Å)