1PFQ

crystal structure of human apo dipeptidyl peptidase IV / CD26

Summary for 1PFQ

• Entry DOI: 10.2210/pdb1pfq/pdb
• Related: 1N1M 1ORV 1ORW
• Descriptor: Dipeptidyl peptidase IV soluble form, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: mch_1, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 170384.61

Authors

Oefner, C.,D'Arcy, A.,Mac Sweeney, A.,Pierau, S.,Gardiner, R.,Dale, G.E. (deposition date: 2003-05-27, release date: 2003-07-01, Last modification date: 2024-11-13)

Primary citation

Oefner, C.,D'Arcy, A.,Mac Sweeney, A.,Pierau, S.,Gardiner, R.,Dale, G.E.
High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.
Acta Crystallogr.,Sect.D, 59:1206-1212, 2003

PubMed Abstract: Dipeptidyl peptidase IV is a multifunctional type II transmembrane serine protease glycoprotein. The high-resolution crystal structure of the homodimeric human apo dipeptidyl peptidase IV has been determined at 1.9 A resolution. In addition, the structure of the binary complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine has been solved, revealing the nature of the covalent interaction with the active-site serine.

PubMed: 12832764
DOI: 10.1107/S0907444903010059

Experimental method

X-RAY DIFFRACTION (1.9 Å)