2BU5
crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
Summary for 2BU5
Entry DOI | 10.2210/pdb2bu5/pdb |
Related | 2BTZ 2BU2 2BU6 2BU7 2BU8 |
Descriptor | PYRUVATE DEHYDROGENASE KINASE ISOENZYME 2, 4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE (3 entities in total) |
Functional Keywords | transferase, pyruvate dehydrogenase kinase 2, ghkl motif regulation |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 45031.10 |
Authors | Knoechel, T.R.,Tucker, A.D.,Robinson, C.M.,Phillips, C.,Taylor, W.,Bungay, P.J.,Kasten, S.A.,Roche, T.E.,Brown, D.G. (deposition date: 2005-06-08, release date: 2006-02-02, Last modification date: 2023-12-13) |
Primary citation | Knoechel, T.R.,Tucker, A.D.,Robinson, C.M.,Phillips, C.,Taylor, W.,Bungay, P.J.,Kasten, S.A.,Roche, T.E.,Brown, D.G. Regulatory Roles of the N-Terminal Domain Based on Crystal Structures of Human Pyruvate Dehydrogenase Kinase 2 Containing Physiological and Synthetic Ligands. Biochemistry, 45:402-, 2006 Cited by PubMed: 16401071DOI: 10.1021/BI051402S PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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