2BU5

crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004740	molecular_function	pyruvate dehydrogenase (acetyl-transferring) kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005654	cellular_component	nucleoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006111	biological_process	regulation of gluconeogenesis
A	0006885	biological_process	regulation of pH
A	0008286	biological_process	insulin receptor signaling pathway
A	0010510	biological_process	regulation of pyruvate decarboxylation to acetyl-CoA
A	0010565	biological_process	regulation of ketone metabolic process
A	0010906	biological_process	regulation of glucose metabolic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0031670	biological_process	cellular response to nutrient
A	0033554	biological_process	cellular response to stress
A	0034614	biological_process	cellular response to reactive oxygen species
A	0042593	biological_process	glucose homeostasis
A	0042803	molecular_function	protein homodimerization activity
A	0045254	cellular_component	pyruvate dehydrogenase complex
A	0050848	biological_process	regulation of calcium-mediated signaling
A	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator

Functional Information from PDB Data

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16401071","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q15118","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8BFP9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1jm6