2BHJ

murine iNO synthase with coumarin inhibitor

2BHJ の概要

• エントリーDOI: 10.2210/pdb2bhj/pdb
• 関連するPDBエントリー: 1DD7 1DF1 1DWV 1DWW 1DWX 1JWJ 1JWK 1M8D 1M8E 1M8H 1M8I 1M9T 1N2N 1NOC 1NOD 1NOS 1QOM 1QW4 1QW5 1R35 1VAF 2NOD 2NOS 3NOD
• 分子名称: NITRIC OXIDE SYNTHASE, THIOCOUMARIN, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• 機能のキーワード: inos, calmodulin-binding, fad, fmn, heme, metal-binding, nadp, oxidoreductase, polymorphism, zinc
• 由来する生物種: MUS MUSCULUS (MOUSE)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49988.59

構造登録者

Mathieu, M.,Guilloteau, J.P. (登録日: 2005-01-12, 公開日: 2005-03-31, 最終更新日: 2023-12-13)

• 主引用文献: Jackson, S.A.,Sahni, S.,Lee, L.,Luo, Y.,Nieduzak, T.R.,Liang, G.,Chiang, Y.,Collar, N.,Fink, D.,He, W.,Laoui, A.,Merrill, J.,Boffey, R.,Crackett, P.,Rees, B.,Wong, M.,Guilloteau, J.P.,Mathieu, M.,Rebello, S.S.; Design, Synthesis and Characterization of a Novel Class of Coumarin-Based Inhibitors of Inducible Nitric Oxide Synthase; Bioorg.Med.Chem., 13:2723-, 2005; PubMed: 15781384; DOI: 10.1016/J.BMC.2005.02.036

実験手法

X-RAY DIFFRACTION (3.2 Å)