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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2BHJ

murine iNO synthase with coumarin inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004517	molecular_function	nitric-oxide synthase activity
A	0006809	biological_process	nitric oxide biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FC1 A1499

Chain	Residue
A	GLN257
A	VAL346
A	TRP366
A	TYR367
A	MET368
A	HEM1500

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HEM A1500

Chain	Residue
A	GLY196
A	GLN199
A	LEU203
A	MET349
A	PHE363
A	TRP366
A	TRP457
A	TYR485
A	FC11499
A	HBI1501
A	TRP188
A	ARG193
A	CYS194

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE HBI A1501

Chain	Residue
A	TRP84
A	SER112
A	MET114
A	ARG375
A	ILE456
A	TRP457
A	PHE470
A	HIS471
A	HEM1500

Functional Information from PROSITE/UniProt

site_id	PS60001
Number of Residues	8
Details	NOS Nitric oxide synthase (NOS) signature. RCIGRIqW

Chain	Residue	Details
A	ARG193-TRP200

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:12464241, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWV, ECO:0007744\|PDB:1DWW, ECO:0007744\|PDB:1N2N

Chain	Residue	Details
A	CYS104
A	CYS109

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:11669619, ECO:0000269\|PubMed:12437348, ECO:0000269\|PubMed:12464241, ECO:0000269\|PubMed:9516116, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWX, ECO:0007744\|PDB:1JWJ, ECO:0007744\|PDB:1M8D, ECO:0007744\|PDB:1M8E, ECO:0007744\|PDB:1M8H, ECO:0007744\|PDB:1M8I, ECO:0007744\|PDB:1M9T, ECO:0007744\|PDB:1N2N, ECO:0007744\|PDB:1NOD, ECO:0007744\|PDB:1QOM, ECO:0007744\|PDB:2NOD, ECO:0007744\|PDB:3NOD

Chain	Residue	Details
A	SER112

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:11669619, ECO:0000269\|PubMed:12437348, ECO:0000269\|PubMed:12464241, ECO:0000269\|PubMed:9334294, ECO:0000269\|PubMed:9516116, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWV, ECO:0007744\|PDB:1DWW, ECO:0007744\|PDB:1DWX, ECO:0007744\|PDB:1JWJ, ECO:0007744\|PDB:1JWK, ECO:0007744\|PDB:1M8D, ECO:0007744\|PDB:1M8E, ECO:0007744\|PDB:1M8H, ECO:0007744\|PDB:1M8I, ECO:0007744\|PDB:1M9T, ECO:0007744\|PDB:1N2N, ECO:0007744\|PDB:1NOC, ECO:0007744\|PDB:1NOD, ECO:0007744\|PDB:1NOS, ECO:0007744\|PDB:1QOM, ECO:0007744\|PDB:2NOD, ECO:0007744\|PDB:2NOS, ECO:0007744\|PDB:3NOD

Chain	Residue	Details
A	CYS194

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P29474

Chain	Residue	Details
A	GLN257
A	TRP366
A	TYR367
A	GLU371

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:11669619, ECO:0000269\|PubMed:12437348, ECO:0000269\|PubMed:12464241, ECO:0000269\|PubMed:9516116, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWX, ECO:0007744\|PDB:1JWJ, ECO:0007744\|PDB:1JWK, ECO:0007744\|PDB:1M8D, ECO:0007744\|PDB:1M8E, ECO:0007744\|PDB:1M8H, ECO:0007744\|PDB:1M8I, ECO:0007744\|PDB:1M9T, ECO:0007744\|PDB:1N2N, ECO:0007744\|PDB:1NOD, ECO:0007744\|PDB:1QOM, ECO:0007744\|PDB:3NOD

Chain	Residue	Details
A	ARG375

site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:12437348, ECO:0000269\|PubMed:12464241, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1M9T, ECO:0007744\|PDB:1N2N

Chain	Residue	Details
A	ILE456

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:12437348, ECO:0000269\|PubMed:12464241, ECO:0000269\|PubMed:9516116, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWX, ECO:0007744\|PDB:1M8D, ECO:0007744\|PDB:1M8E, ECO:0007744\|PDB:1M8I, ECO:0007744\|PDB:1M9T, ECO:0007744\|PDB:1N2N, ECO:0007744\|PDB:1NOD, ECO:0007744\|PDB:1QOM, ECO:0007744\|PDB:2NOD, ECO:0007744\|PDB:3NOD

Chain	Residue	Details
A	TRP457

site_id	SWS_FT_FI8
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:11669619, ECO:0000269\|PubMed:12437348, ECO:0000269\|PubMed:12464241, ECO:0000269\|PubMed:9516116, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWX, ECO:0007744\|PDB:1JWJ, ECO:0007744\|PDB:1JWK, ECO:0007744\|PDB:1M8D, ECO:0007744\|PDB:1M8E, ECO:0007744\|PDB:1M8H, ECO:0007744\|PDB:1M8I, ECO:0007744\|PDB:1N2N, ECO:0007744\|PDB:1NOD, ECO:0007744\|PDB:1QOM, ECO:0007744\|PDB:2NOD, ECO:0007744\|PDB:3NOD

Chain	Residue	Details
A	PHE470

site_id	SWS_FT_FI9
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:9516116, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWX, ECO:0007744\|PDB:1NOD, ECO:0007744\|PDB:1QOM, ECO:0007744\|PDB:2NOD, ECO:0007744\|PDB:3NOD

Chain	Residue	Details
A	TYR485

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 3nos

Chain	Residue	Details
A	TRP366
A	ARG197
A	CYS194
A	GLU371

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PDB entries from 2024-10-09

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